NICI Advisory Board Member and Senior Advisor to the Israel Ministry of Health, Dr. Michael Dor, has a lot to say about the future of cannabis research and just where to find the biggest opportunities.

Cannabis legalization is an incredibly disruptive force.

As a Senior Medical Advisor at the Israeli Ministry of Health’s Medical Cannabis Unit, I get to see much of this disruption first hand. And as an Advisory Board Member for the National Institute of Cannabis Investors, you’ll be hearing from me about some of the incredible opportunities in cannabis science driving this disruption.

Ending prohibition will ultimately legitimize hundreds of billions of black market marijuana sales. And bringing these sales into the legal light means revenues – and profits – for cannabis entrepreneurs, investors, and businesses.

But the industry that is rapidly emerging will do far more than shift these revenues from one set of pockets to the other. It will create entirely new markets on the back of even larger, far more established industries.

This eruption of opportunity onto a field with such a large, pre-existing market has resulted in a massive acceleration of cannabis research and product development during the last few years. Fueling this acceleration is the number of countries and companies promoting or sponsoring research into new medicinal and recreational cannabis products.

This list grows daily, and understanding how the compounds found in cannabis work together lies at the heart of much of this research.

But what we are finding takes us far beyond common cannabis knowledge…

Beyond THC and CBD

The first direction of research and product development is to clearly distinguish cannabidiol (CBD) from tetrahydrocannabinol (THC).

Because these two compounds are so prevalent in the cannabis plant, the known effects of CBD and THC are far better understood than the other cannabinoids.

Of these two, CBD is the primary cannabinoid ingredient without psychoactive activity. It is effective in controlling pain and suppressing immune activities – and we get these benefits without paying the price of the psychoactive side effects that come with the use of THC. This difference makes CBD products more attractive for most applications.

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Unfortunately, treating and curing diseases is not that simple.

The cannabis plant includes 150 cannabinoids and two more groups – flavonoids and terpenes. The exact role of each ingredient is not clear, but we are learning that in most cases using a single cannabinoid – one of the 150 – does not work.

The pharmaceutical companies that make the most of this effect stand to gain significantly, while those that don’t could see their profit models threatened.

And the true breakthrough will come from understanding how they all work together.

A Family Effect

From the research, it is obvious that a better effect can be achieved by using the whole plant.

Doing so provides exposure to all of the cannabinoids, plus the terpenes and flavonoids. But the relative percentage of the components is the key to the desired effect.

Professor Raphael Mechoulam, who was the first person to identify THC, called this phenomenon “the entourage effect.” We also used to call it “the Familia effect.” The specific cannabinoid is not nearly as strong when it is alone – it needs “family” support to do the work.

When you have hundreds of ingredients, and you don’t know which one is effective and what combination is needed to cure different diseases, it is difficult to plan research and develop a program and produce medications. Matters are even more complicated because the content of the plant changes frequently as a result of many factors like light or temperature. For real research, you need the amounts and proportions of cannabinoids, flavonoids, and terpenes to remain constant during the entire course of research.

But while it is important to understand the entourage effect, it is very unlikely that all the cannabinoids are needed all the time.

Allow me to share a powerful example of the phenomenon I’m writing about.

Working Together Against Cancer

Two teams of Israeli researchers tried to identify the cannabinoids that are capable of stopping the growth of different cancer tissues. The results were really promising. They succeeded, using a process of elimination, to identify four cannabinoids that “did the job” and stopped the cancer’s tissue growth. Removing any of the four cannabinoids caused the effect to disappear.

Those results gave a new and deeper understanding to the meaning of the entourage effect.

It was also a very promising direction for the future development of anti-cancer medications.

These new directions include identification of the genetics of the plant and the ability to identify the human genetics so we will be able to achieve a matching that will enable a truly “personalized medicine.”

The expectations for the future include more specific knowledge of other cannabinoids and the ability to make the matching between the specific combinations of cannabis and the different diseases.

And there is no doubt we are just beginning to learn about all that the cannabis plant has to offer.

And to understand why my friends at the National Institute of Cannabis Investors have dubbed 2019 the “Year of CBD,” take a look at this free, comprehensive report.

Dr. Michael Dor
Senior Medical Advisor, Israeli Ministry of Health

P.S. Forbes reports that, by 2022, we could have more cannabis jobs in the U.S. than manufacturing jobs. This, along with potential tax revenue, is a huge sell for politicians in the race to federal legalization. Even with current federal regulations on the cannabis industry, our experts predict it will reach $50 billion within five years. If – or when – the federal government legalizes cannabis, the industry could double almost overnight to $100 billion in the United States alone. The experts here at the National Institute for Cannabis Investors have our top four pot stocks you need to know about before this market potentially explodes. To find out more information, go here now.


9 responses to “It Takes More than Common Cannabis Knowledge to Profit”

  1. Thank you Dr. Michael Dor. Entourage effect provides the best healing for myself, don’t people want non GMO, natural plant based healing?

  2. It is really incredible that cannabis has all these properties. And milk weed doesn’t. Nor does crab grass or dandelions. The most common perception is the obvious recreational properties. It’s just that history has such a long record of snake-oil remedies. Just look at the supplement section at the drug store. Milk thistle, St. John’s wart, saw palmetto, etc. Do they work? Perhaps the placebo effect?

    I remember they would say if you are getting a cold, take vitamin C. No, not just any vitamin C, you need C with bioflavinoids with rose hips. People used to brag about their vitamins. But many compounds have gone the way of the hoola-hoop and ‘pet rock’.

    Of course nobody wants rickets, scurvy, a goiter, or even a headache. So, we take vitamin D, C, iodine, and synthesized willow bark . Unmistakably proven remedies.

    Then of course, nobody wants PTSD, depression, epilepsy, or whatever. What I’m saying is, I’ve stopped buying vitamins and now I have a few more salads and call it good. For CBD to be more than a half dead bottle of vitamin E in my cupboard I’m going to need a Lot of convincing. Guess you have your work cut out Doctor Dor.

    Keep up your valuable work because the people Really want to believe in the medicinal claims of hemp. Many of us need more proof before stocking the cupboard. –JG

  3. I’m learning about an industry that was purely for recreational use in my day. The medical potential this plant can and will have to humanity is encouraging, both medically and monetarily. Thanks sharing what our future can look like.

  4. Is it known that THC is the only pyschoactive compound in cannabis?
    If so, would it be reasonable to first investigate the whole plant minus the THC to see that it (a) has good effects on disease, and (b) no terrible side effects? Not only easier, but avoids the combinatoric explosion of trying to understand everything from a minimalistic approach.

  5. Some of us have known for years now that whole plant extract kills cancer. We’ve been impatiently waiting for a time when knowledgable people can finally do the research on it. I’ve saved a lot of lives and done miracles but I still don’t know how. We have to take the plant apart and see what we can put together constructively. There’s amazing properties of this plant that I hope are about to be discovered.

  6. This isn’t surprising to me. I’m a 6-time breast cancer survivor who’s had more than 20 surgeries, 5 full courses of radiation & over 250 chemotherapy/infusion treatments. I began using cannabis regularly for chronic pain and only now – for the first time in the 25 years I’ve had cancer – have I reached 5 years cancer free. I believe we’ll see the scientific evidence for the health benefits of cannabis explode over the next several years.

  7. I am fused from C-2 to T-3 and I’ve heard about the good effects of “CBD OIL’S” so i tried it! It did not work for me, but my 12 yr old Pit Bull was having trouble getting up and down, back legs did not want to work, stiff. So I thought why not, i gave a shot to Baby Girl. Within 30 min she was up walking around, playing with other dogs! I’m a firm believer in CBD products. Not to mention the effects it has on my sister with MS!

  8. Dr. Dor, can you please explain how TNF or Tumor Necrosis Factor and whole plant extract correlate? Can you elaborate on how Rick Simpson Oil or almost any pure THC (whole plant) extract suppress inflammation, eats and destroys cancer tumors and cells? When is science going to catch up with reality? It is well known that cannabis is a potent healer and it has allowed people to live normal lives where they otherwise wouldn’t. What’s it going to take to study cannabis and put out official results? It’s very sad that people are dying and suffering everyday, and we must wait for more to die and become ill until congress allows slow moving legislation to procede. How many more people will have to die and suffer before we get justice?

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